Description of Methandrostenolone (Dianabol)

Methandrostenolone is a powerful enough steroid, which gives a significant increase in body weight due to the accumulation of water in the body, as well as an increase in strength. Methandrostenolone is strongly aromatized, so when taking it, you need to take aromatase inhibitors to control the performance of Estradiol, which in turn will avoid unnecessary water retention in the body.

History of Methandrostenolone

Methandrostenolone was described in 1955. It was released on the American market in 1958 by the Ciba company called dianabol. Ciba promoted methandrostenolone with the help of physician John Ziegler, who was the physician of many US Olympic teams. Ziegler at the competitions noted that Soviet athletes abuse testosterone. According to Ziegler, this hormone had significant side effects, and one of the athletes had such a strong prostate enlargement that he needed a catheter for urine. Working with Ziegler, Ciba tested the androgenicity of the created methandrostenolone. Ziegler’s athletes have made great strides on methandrostenolone.

By the beginning of the 1960s it became like a general use. Ziegler’s recommendations on the use of 5-15 mg per day were ignored, and athletes used more aggressive dosages. Ultimately, this led to the fact that Ziegler moved into opposition. In 1967, about 10 years after the start of the application, Ziegler categorically condemned the use of AAS athletes for sporting events. In 1965, the FDA turned its attention to methandrostenolone. The company was required to explain the purpose of the drug, and then it was stated that it was required to treat patients with malnutrition and weak bones. In 1970, he was recognized as “probably effective” for the treatment of osteoporosis and pituitary dwarfism.

These changes are reflected in the prescription of the drug in the 1970s. Ultimately, the company lost patent rights and many other companies began to produce it. By the early 80’s, the FDA required large data on the treatment of dwarfism. Dianabol was threatened with leaving the US market, despite the fact that in other countries it was used as the main sport dope.

Product Forms

Methandrostenolone is widely distributed in the pharmacy and veterinary markets. The composition and dosage may vary depending on the country and the manufacturer. Methandrostenolone was first issued in tablets of 2.5 mg and 5 mg (dianabol). Modern brands often contain 5 mg or 10 mg in a tablet. Methandrostenolone can also be found in the form of injectable veterinary drugs. A typical dosage in this case is 25 mg / ml.

Structural Features

Methandrostenolone is a modified testosterone. It is different:

  1. by the addition of a methyl group at the 17 alpha position, which allows the preparation to be protected when ingested,
  2. by introducing a double bond between Carbon 1 and 2, which shifts the ratio of anabolicity and androgenity to the former.

The resulting steroid has less ability to bind to androgen receptors, but at the same time shows a much longer half-life compared with testosterone, and a lower ability to bind to blood binding proteins. These features allow methandrostenolone to be a very potent anabolic steroid, despite the weaker ability to bind to receptors. A recent study also confirmed that its main mode of action involves interaction with cellular androgen receptors.

Estrogenic Side Effects

Methandrostenolone is aromatized and has moderate estrogenic activity. Gynecomastia often causes anxiety during admission, and can manifest itself at the beginning of the course, especially at high doses. At the same time, water retention may become a problem, which will cause loss of the drawing. Sensitive people can keep estrogen under control with anti-estrogens such as tamoxifen or proviron. You can alternate their reception with an aromatase inhibitor, such as arimidex, but this can be an expensive option and can have a negative effect on lipid levels. It is interesting to note that methandrostenolone is structurally identical to boldenone, except that boldenone does not have a c17-alpha methyl group. This makes it clear why such similar substances have different effects on the body. The key factor here is estrogenic side effects. Boldenone is usually taken at all without anti-estrogens. Methandrostenolone is much more estrogenic. But this does not mean that methandrostenolone is faster flavored. In fact, c17-alpha and double bond 1-2 significantly slow down the process of aromatization. The problem is caused by the fact that methandrostenolone is converted to 17-alpha-methyl estradiol, a more biologically active form of estrogen than estradiol.

Androgenic Side Effects

Methandrostenolone is classified as anabolic, but androgenic side effects are still possible. It can be increased skin fatness, acne, hair growth on the body and face. High doses are likely to cause them. Anabolic steroids can worsen male hair loss. People sensitive to androgenic effects of methandrostenolone, it is better to switch to another drug, such as nandrolone decanoate. Women in addition need to remember the potential virilizing effects of AAS. This may include coarsening of the voice, irregular periods, changes in the structure of the skin, growth of facial hair, and an increase in the clitoris. Methandrostenolone reacts with 5a-reductase and turns into a more potent androgen-dihydromethandrostenolone, but its amount is small, and the relative androgenicity of methandrostenolone can not be significantly altered by the parallel application of finasteride or dutasteride.

Reception Methandrostenolone

Dianabol is produced in tablets, and therefore used orally. The normal course duration is 6-8 weeks. As for dosages, if you have not previously used dianabol, start taking the drug with a minimum of 5-10 mg to check the susceptibility of the body to the drug.

When you find out that the body responds normally to the how to take dianabol, side effects do not appear, it is advisable to increase the dosage to 20-30 mg daily. More experienced athletes can increase it to 50 mg daily. The drug is divided into several portions throughout the day. This will ensure a constant flow of active substance into the bloodstream and reduce the load for your liver. Take the drug after eating.

In the course of the course, it is advisable to use drugs with anti-estrogenic activity to avoid conversion of excess testosterone into estrogens, beginning approximately from the second week of the cycle of the course. After the completion of the course, it is also necessary to carry out the PBC in order to eliminate the phenomenon of recoil.

In order to achieve better results, it is advisable to use dianabol not solo, but in conjunction with other anabolic steroids, which will provide a synergistic effect. Fortunately, the price of dianabol allows this.

 

 

 

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