Maximum concentration level is determined after about 40 – 60 minutes. Food intake has no significant effect on the amount of absorption, but in this case the rate of absorption is reduced slightly. Distribution: cetirizine is bound to plasma proteins for dianabol side effects about 93%. The value of volume of distribution (Vd) is low (0.5 l / kg), the drug does not penetrate into the cells. The drug does not penetrate the blood-brain barrier. Metabolism: cetirizine poorly metabolized in the liver with the formation of inactive metabolite.
At 10-day application of 10 mg drug accumulation was observed. Excretion: about 70% occurs mainly by kidneys in unchanged form. The magnitude of systemic clearance is about 54 ml / min. After a single dose administration of a single value of half-life is about 10 hours. In children aged 2 to 12 years the value of half-life is reduced to 5-6 hours. If the kidney function (creatinine clearance below 11-31 ml / min) and in patients on hemodialysis (creatinine clearance less than 7 ml / min) half-life value is increased by 3 times, decreased clearance by 70%. on the background of chronic diseases, and elderly patients there is an increase in half-life values of 50% and a decrease in clearance of 40%.Hemodialysis ineffective.
Indications for use
year-round and seasonal allergic rhinitis (symptomatic therapy); urticaria, including chronic idiopathic; dermatoses proceeding with itching (atopic dermatitis, neurodermatitis); allergic conjunctivitis.
Increased sensitivity to dianabol side effects cetirizine or other components of the drug; severe kidney disease.
Children under 6 years of age.
Chronic pyelonephritis secondary to severe (requires correction mode), advanced age (perhaps decreased glomerular filtration).
Dosing and Administration
Inside, regardless of meals, without chewing and drinking plenty of fluids, preferably in the evening. Children aged 6 to 12 years:
- birth weight of less than 30 kg for ½ coated tablet in the evening
- with body weight over 30 kg: 1 tablet, coated in the evening.
You can also receive 2 times a day (morning and evening) for ½ tablets. Adults and adolescents over the age of 12 years is recommended to take 1 tablet of cetirizine, preferably in the evening. In renal insufficiency, should reduce the recommended dose is 2 times. If abnormal liver function must be selected the dose individually, especially careful while renal insufficiency. Elderly patients with normal renal function dose adjustment is required. In seasonal allergic rhinitis duration of therapy is usually 3 to 6 weeks, and it is enough and dianabol side effects one week with short-term exposure to pollen. The duration of therapy for children older than 6 years is from 2 to 4 weeks, but for short periods of reception of an allergen sufficient for 1 week.
Side effects From the digestive system: dry mouth, dyspepsia. CNS: headache, drowsiness, fatigue, dizziness, agitation, migraine. Allergic reactions: . Skin rash, angioedema, urticaria, pruritus The drug is generally well tolerated. Side effects are rare and are transient in nature.
Overdose Symptoms: possible drowsiness, lethargy, weakness, headache, tachycardia, irritability, urinary retention, fatigue (often while taking daily 50 mg of cetirizine). Treatment: symptomatic therapy. A specific antidote is not revealed. Hemodialysis is ineffective. Perform gastric lavage, activated charcoal.
Interaction with other drugs
not identified clinically significant interactions of cetirizine with other drugs.
Joint use with theophylline (400 mg / day) reduces total clearance of cetirizine (kinetics of theophylline is not changed).
In the period of treatment should refrain dianabol side effects from activities potentially hazardous activities that require high concentration and psychomotor speed reactions.
It is not recommended the simultaneous use of drugs which depress the central nervous system, alcohol.