For parenteral administration of ceftriaxone well penetrates the tissues and body fluids.
The area under the curve “concentration – time” in the serum after intravenous and intramuscular administration of the same. This means that the bioavailability of ceftriaxone administered intramuscularly is 100%. When dianabol for sale intravenous ceftriaxone diffuses rapidly into the interstitial fluid, where its bactericidal activity against susceptible thereto pathogens retains for 24 hours.
Reversibly bound to albumin, and this binding is inversely proportional to the concentration of, for example, at a concentration in the blood serum of the drug is less than 100 mg / l protein binding is 95%, and at a concentration of 300 mg / l – only 85%. Due to the lower content of albumin in the interstitial fluid ceftriaxone concentration therein is higher than in blood serum.
The half-life in healthy adult subjects is about 8 hours. Newborn to 8 days and the elderly over 75 years, the average half-life of approximately twice. In adults, 50-60%) of ceftriaxone is excreted unchanged form in the urine, and 40-50%> – in unchanged form with bile. Under the influence of the intestinal flora ceftriaxone converted into an inactive metabolite. In newborns about 70%) of the administered dose excreted by the kidneys. When kidney failure or liver disease in adults pharmacokinetics of ceftriaxone is almost unchanged, elimination half-life is lengthened slightly. If renal function is impaired, increased excretion in the bile, and if there is a liver pathology, the enhanced release of ceftriaxone kidneys. Penetration into the cerebrospinal fluid: in infants and in children with inflammation of the meninges ceftriaxone penetrates into the cerebrospinal fluid, while in the case of bacterial meningitis on average 17% of the drug concentration in serum diffuses in the cerebrospinal fluid, which is about 4 times greater than in aseptic meningitis. 24 hours after intravenous dianabol for sale administration of ceftriaxone 50-100 mg / kg body weight concentration in the cerebrospinal fluid higher than 1.4 mg / l. In adult patients with meningitis over 2-25 hours after administration of ceftriaxone 50 mg / kg body weight several times higher than the concentration of ceftriaxone depressing the minimum dose required to inhibit the pathogens most frequently causing meningitis.
Infections caused by sensitive pathogens: sepsis, meningitis, abdominal infections (peritonitis, inflammatory diseases of the gastrointestinal tract, biliary tract) infections of bones, joints, connective tissue, skin, infection in patients with lowered immunity, infection kidney and urinary tract, respiratory tract infections (including pneumonia), and upper respiratory tract infections, urogenital infections (including gonorrhea). Preventing infections in the postoperative period.
: Hypersensitivity to cephalosporins dianabol for sale and penicillin. The first trimester of pregnancy.
of hyperbilirubinemia in newborns, premature babies, kidney / liver failure, ulcerative colitis, enteritis or colitis associated with the use of antibacterial drugs, pregnancy trimester 2-3, lactation.